1743. First Lutheran church in Maryland built under David Candler's leadership, Monocacy River.
1745. Daniel Dulany the Elder laid out Frederick Town and invited German settlement.
1747, May. Reformed Lutheran congregation organized by Michael Schlatter in Frederick.
1748, Dec. 10. Frederick County formed from parts of Baltimore County and Prince George's County.
1755, April 23. British Gen. Edward Braddock, Col. George Washington, and Ben Franklin met at Frederick to plan British assault on Fort Duquesne.
1756. Assembly supplied funds for Fort Frederick, near North Mountain.
1765, Nov. 23. Stamp Act resistance at Frederick.
1774. Catoctin Iron Furnace, Frederick County.
1775, July 18. Rifle companies under Michael Cresap and Thomas Price departed Frederick Town to join Washington's army at Boston.
1776. Montgomery County created from eastern Frederick County.
1776. Washington County created from western Frederick County.
1777. Hessian Barracks constructed at Frederick held Hessian mercenaries and British troops captured at Battle of Saratoga, and later battles.
1784. John Frederick Amelung and party established New Bremen glassworks, Frederick County.
1786. Matthias Bartgis began newspaper publishing in Frederick.
1787. Toll roads connecting Baltimore with Frederick, Westminster, Hanover, and York authorized by General Assembly.
1792, Aug. 5-1793, Jan. 16. Thomas Johnson (1732-1819) of Frederick County served on U.S. Supreme Court.
1799, Feb. 3. Francis Thomas (1799-1876), Governor of Maryland, born near Burkittsville.
1807. National Road began as Baltimore and Frederick Town Turnpike.
1808. John Dubois (1764-1842) established Mount St. Mary's College (now Mount St. Mary's University), Emmitsburg.
1809. Elizabeth Ann Seton (1774-1821) adopted modified rule of Sisters of Charity, established order in Emmitsburg.
1809. St. Joseph's College, Emmitsburg, founded.
1816. Frederick incorporated.
1820, Aug. 10. Enoch Louis Lowe (1820-1892), Governor of Maryland, born in Frederick.
1822, May 23-24. As the Cattle Show and Fair, the first Frederick County Fair began at George Greager's Tavern at Monocacy Bridge.
1824. Emmitsburg incorporated.
1831. Thurmont incorporated.
1831, July 20-1833, Nov. 14. Roger Brooke Taney (1777-1864) of Frederick served as U.S. Attorney General.
1833. Middletown incorporated.
1833, Sept. 23-1834, June 25. Roger Brooke Taney (1777-1864) of Frederick served as U.S. Secretary of the Treasury.
1836. Woodsboro incorporated.
1836, March 15-1864, Oct. 12. Roger Brooke Taney (1777-1864) of Frederick served as Chief Justice, U.S. Supreme Court.
1837. Carroll County created from parts of Frederick and Baltimore counties.
1843, July-1845, March. John Nelson (1791-1860) of Frederick served as U.S. Attorney General.
1844, Feb. 29-March 31. John Nelson (1791-1860) of Frederick served as U.S. Secretary of State ad interim.
1845, Feb. 20. Frederick Town and Emmitsburg Turnpike chartered.
1859, July 3-Oct. 16. John Brown (1800-1859) prepared for raid on Harper's Ferry from Kennedy Farmhouse at Sandy Hook.
1861, April 26. General Assembly met in special session at Frederick.
1861, Aug. 10-Nov. 27. Cole's Cavalry, Companies A, C & D, organized at Frederick.
1862, Oct. 10-12. Gen. J.E.B. Stuart's cavalry rode through Washington, Frederick and Montgomery counties during raid into Pennsylvania.
1863, June 17. Cole's Cavalry fought at Catoctin Creek.
1863, June 22. Cole's Cavalry fought at Frederick.
1864, July 9. Frederick held for ransom by Confederate forces under Gen. Jubal Early.
1864, July 9. Battle of Monocacy; Confederates defeated Gen. Lew Wallace, and sent cavalry raiders north of Baltimore, then back through Prince George's County.
1870, Feb. 17. Page Williams lynched at Point of Rocks.
1878. New Market incorporated.
1884. George Alfred Townsend (1841-1914), author and war correspondent, began building Gathland near Burkittsville.
1887. Katy of Catoctin or the Chain-Breakers: A National Romance, by George Alfred Townsend (1841-1914), published.
1887, Nov. 23. John H. Biggus lynched in Frederick.
1890. Brunswick incorporated.
1892. Walkersville incorporated.
1893. Women's College of Frederick founded, later became Hood College.
1894. Burkittsville incorporated.
1894. Mount Airy incorporated.
1895, Nov. 16. James Bowens lynched in Frederick.
1896. War Correspondents' Memorial Arch, the first monument to war journalists, built by George Alfred Townsend (1841-1914) at Gathland.
1899, May 4. Henry Darley lynched in Libertytown.
1904. Myersville incorporated.
1905, May 24. Fashion designer, Claire McCardell (1905-1958) born in Frederick.
1922. Ku Klux Klan rallied in Frederick and Baltimore.
1942. President Franklin D. Roosevelt visited "Shangri-la" (later Camp David).
1943. U.S. Army Biological Warfare Laboratories established at Camp Detrick.
1953. Rosemont incorporated.
1956. Camp Detrick renamed Fort Detrick.
1956. I-70 (east) connected Frederick and Baltimore.
1957. I-70 (south) connected Frederick and Washington, DC.
1970. I-70 (west) opened from Frederick to Hancock.
1975. Elizabeth Ann Seton (1774-1821) canonized by Pope Paul VI.
1975, May 18. I-70 (south) renamed I-270.
1978. Sept. 5-17. Camp David Accords negotiated at Camp David, Frederick County, between President Jimmy Carter, President Anwar Sadat of Egypt, and Prime Minister Menachem Begin of Israel. Signed in Washington, DC, March 26, 1979.
1989. Frederick Keys, minor league baseball team, established at Frederick.
2004, March 2. Electronic voting system used during primary elections at polling places and for absentee ballots in all counties and Baltimore City.
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